11110E500100 College of Engineering Seminar

TOPIC
▸　Bioengineering Approaches for Enhancing Therapeutic Efficacy of Cell Therapy

Abstract
❝　Cell transplantation has been demonstrated to be a promising therapy for treating various diseases and injuries. In conventional cell therapies, cells are trypsinized, harvested, and transplanted into the lesion area. However, massive cell loss may occur owing to mechanical leakage, cell detachment-associated anoikis, or the hostile microenvironment in target tissue, thus limiting the ultimate therapeutic capacity. Herein, we aim to enhance the retention, survival, and pro-regenerative capacities of the engrafted cells by (i) assembling them into three-dimensional (3D) spheroids and (ii) modulating the microenvironment of the target area using functional biomaterials. Our in vitro and in vivo results demonstrate that transplanting cells in 3D-spheroid configuration that comprise of cells and the deposited matrices and growth factors provides a superior therapeutic effect than that of simple cell suspension. Moreover, the developed functional biomaterials help establish a suitable microenvironment for the engrafted cells to survive and conduct regeneration. Therefore, we anticipate that the proposed approaches can offer promising means to enhance the therapeutic efficacy of cell transplantation. 　❞

SPEAKER
▸　Prof. Chieh-Cheng HUANG
▸　Institute of Biomedical Engineering, National Tsing Hua University

TIME
▸　2022/11/01 (TUE) 13:20 ~ 15:20

VENUE
▸　Auditorium Room 106, Engineering Building 1