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[COE Seminar] 2024/05/07: "Point-of-Use (PoU) Diagnostics using Magnetic and Bioelectronic Approaches" - Prof. Chih-Cheng HUANG, Precision Medicine Ph.D. Program, College of Life Sciences and Medicine, NTHU

11220E500100 College of Engineering Seminar

▸ Point-of-Use (PoU) Diagnostics using Magnetic and Bioelectronic Approaches

❝ Facing unprecedented population-ageing, the growing impact of noncommunicable diseases (NCDs) necessitates evolution in the contemporary healthcare system that was designed many decades ago. One of the key enablers is to transition diagnostics from centralized laboratories closer to patients in point-of-use (PoU) settings, which provide high effectiveness, low cost, easy access, and fast turnaround. Optical-based instrumentation is still the workhorse in clinical diagnostics, while it hardly translates to a PoU device due to requirement of complex optics, lasers, and photodetectors. 

To better address NCD management, a magnetic biosensor provides PoU-friendly settings like matrix-insensitivity, rapid turnaround time, and miniaturization without a loss of sensitivity. In this talk, magneto-biosensing techniques are presented with both cellular and molecular assays. A magnetic flow cytometer (MFC) using a giant magnetoresistive (GMR) biosensor and matched filtering is developed to perform aptamer-based cancer cell detection, exhibiting an affordable signal-to-noise ratio (SNR) down to 2.5 dB. In terms of the molecular assay, magnetorelaxometry (MRX) is implemented with GMR sensors and bioelectronics, demonstrating the first realization of GMR-based time-domain MRX bioassays.

▸ Prof. Chih-Cheng HUANG
▸ Precision Medicine Ph.D. Program, College of Life Sciences and Medicine, National Tsing Hua University

Short Bio
❝ Dr. Chih-Cheng (Iric) Huang is currently an assistant professor in Precision Medicine Program, National Tsing Hua University (NTHU). He received the B.S. degree in materials science and engineering from National Taiwan University (NTU) in 2010, the M.S. degree in nanoengineering and microsystems from NTHU in 2012, and the Ph.D. degree in materials science and engineering from the University of California – San Diego (UCSD) in 2020. Dr. Huang extensively researches cutting-edge semiconductor devices and their applications on biosensors and bioelectronics, by which precision diagnostics transforms the healthcare system from a one-size-fits-all model to a personalized framework. Since 2010, he has cross-disciplinarily worked on III-V compound, high electron mobility transistors (HEMTs), magnetoresistive devices, nanomaterials, BioMEMS, biomedical signal processing, cancer diagnostics, and targeted proteomics.

▸ 2024/05/07 (TUE) 13:20 ~ 15:10

▸ Classroom 202, Chemical Engineering Building

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